Bob Clark has asked me to draw your attention to this upcoming symposium: A symposium is being organized for this fall's ACS meeting in Washington DC (Aug 28-Sep 1, 2005) entitled: (Q)SAR in Today's Agrochemistry The discovery and development of any biologically active small molecule necessarily entails biological or biochemical testing of candidate compounds and relating the results obtained from such testing back to chemical structure, i.e., establishing structure activity relationships (SARs). This symposium will embrace application of qualitative as well as quantitative analytical methods to agrochemical problems in particular and to in vivo (or ex vivo) assays in general, as well as lead identification (triage) techniques. Talks related to the design of primary and secondary screens will also be appropriate, particularly as they relate to the ability to subsequently carry out meaningful SAR analysis. Many of the difficulties encountered in constructing structure-activity relationships using agrochemical data are also encountered by those in pharmaceutical discovery and development who work, as is more and more common, with whole cell assays. This includes many of the environmental, toxicological and ADME screens now in use in both industries. The symposium is being organized to provide a forum for those with experience in this general realm to share what they have learned with those coming from a more enzyme-based SAR background. Papers involving agrochemical applications are especially encouraged, but any discussion of the challenges that arise in similar applications - e.g., whole cell and intact animal assay systems - are invited as well. Please submit abstracts directly to the OASYS system: http://oasys.acs.org/acs/230nm/agro/papers/index.cgi The deadline for abstract submission is April 26, 2005. Bob Clark Tripos, Inc. 1699 S. Hanley Rd. St. Louis MO 63144 bclark@tripos.com Wendy Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com