Bob Clark has asked me to draw your attention to this upcoming
symposium:
A
symposium is being organized for this fall's ACS meeting in
(Q)SAR
in Today's Agrochemistry
The
discovery and development of any biologically active small molecule necessarily
entails biological or biochemical testing of candidate compounds and relating
the results obtained from such testing back to chemical structure, i.e.,
establishing structure activity relationships (SARs). This symposium will embrace application
of qualitative as well as quantitative analytical methods to agrochemical
problems in particular and to in vivo (or ex vivo) assays in general, as well
as lead identification (triage) techniques. Talks related to the design of primary
and secondary screens will also be appropriate, particularly as they relate to
the ability to subsequently carry out meaningful SAR analysis.
Many
of the difficulties encountered in constructing structure-activity
relationships using agrochemical data are also encountered by those in
pharmaceutical discovery and development who work, as is more and more common,
with whole cell assays. This
includes many of the environmental, toxicological and ADME screens now in use
in both industries. The symposium
is being organized to provide a forum for those with experience in this general
realm to share what they have learned with those coming from a more
enzyme-based SAR background.
Papers
involving agrochemical applications are especially encouraged, but any
discussion of the challenges that arise in similar applications - e.g., whole
cell and intact animal assay systems - are invited as well. Please submit
abstracts directly to the OASYS system:
http://oasys.acs.org/acs/230nm/agro/papers/index.cgi
The
deadline for abstract submission is
Bob
Clark
Tripos,
Inc.
Wendy
Dr. Wendy A. Warr
Wendy Warr & Associates
Tel./fax +44 (0)1477 533837