...forwarded, for your information, Martin -------- Original Message -------- Subject: [neuroscience-technology-network] Bioengineering Seminar "Genes into Geometry; Imaging for Mouse Phenotyping" - 25 April, 4pm Date: Thu, 19 Apr 2012 15:39:13 +0000 From: Fenton, Rob J <r.fenton@imperial.ac.uk> To: neuroscience-technology-network <neuroscience-technology-network@imperial.ac.uk> Dear Colleague, Please note we have another exciting speaker for next week’s Department of Bioengineering seminar. Prof Mark R Henkelman, University of Toronto “Genes into Geometry; Imaging for Mouse Phenotyping” 4pm 25th April Royal School of Mines room 2.28 All welcome Genes into Geometry: Imaging for Mouse Phenotyping Genetically identical inbred strains of mice have remarkably similar anatomical patterning with the spatial variance in the brain limited to only 100 microns. Genetic changes, even when they are very small, frequently result in changes in the geometric patterning. Three-dimensional imaging methods can be used effectively to map anatomical patterning in wild type and genetic disease models in mice. Combined with precise quantitative statistical analysis, geometric differences can be identified and used to map phenotypic abnormalities. The methodology for this kind of analysis will be described using magnetic resonance (MR) imaging, computed tomography (CT), ultrasound (US), and optical projection tomography (OPT). Example applications, mainly from neurosciences, will be presented including neuroplasticity in learning and memory, disease models such as Huntington’s disease, schizophrenia and Autism Spectrum Disorders. A mouse model of aortic plaque caused by disturbed flow will also be presented. http://www.sickkids.ca/AboutSickKids/Directory/People/H/Mark-Henkelman.html -- "There are only 10 kinds of people in the world: those who understand binary and those who don't" Prof. C. Ross Ethier Head, Department of Bioengineering Royal Society Wolfson Research Merit Award Holder Imperial College London South Kensington Campus London SW7 2AZ United Kingdom Email: r.ethier@imperial.ac.uk Phone/Fax: +44 (0)20 7594 9795/9787 Assistant: +44 (0)20 7594 9794 http://www3.imperial.ac.uk/people/r.ethier www.imperial.ac.uk/osteoarthritis Medical Engineering Solutions in Osteoarthritis Centre of Excellence Funded by the Wellcome Trust and the EPSRC Using emerging technologies to change the paradigm by which osteoarthritis is managed