...forwarded for your information; should be interesting to many microscopists working on the analysis of cell tracking and movement, Martin -------- Original Message -------- Subject: CISBIO seminar, Mo, 4pm, October 15 Date: Mon, 8 Oct 2012 10:56:42 +0100 From: Endres, Robert G <r.endres@imperial.ac.uk> To: Krishnan, J <j.krishnan@imperial.ac.uk>, Briggs, Tania J <t.briggs@imperial.ac.uk>, Skene, Barbara <b.skene@imperial.ac.uk>, Buck, Dorothy E <d.buck@imperial.ac.uk>, Marenzana, Massimo <m.marenzana@imperial.ac.uk>, De Simone, Alfonso <a.de-simon@imperial.ac.uk>, melda.tozluoglu@cancer.org.uk <melda.tozluoglu@cancer.org.uk>, Spitaler, Martin <m.spitaler@imperial.ac.uk> Can you please advertise this excellent talk in your area? Many thanks, Robert ------------------ Dear All, Prof. Robert Insall from the Beatson Institute of Cancer Research in Glasgow will give a CISBIO seminar on Monday, 15th October, in G47B Flowers from 4-5pm. Everyone is welcome to attend. If you would like to meet the speaker, please let me know. Title and abstract: "Multiple approaches to control of cell movement and chemotaxis: SCAR/WAVE regulation, computational analysis of cell movement, and efficient simulation of chemotaxis by a simple algorithm" Eukaryotic cells mainly move using actin structures collectively known as pseudopods. While many authors describe pseudopods as the end result of a signalling pathway, our data suggest a different picture - that pseudopods are autonomous structures that propagate themselves through feedback loops. In this, "pseudopod-centred" model, chemotactic signals steer cells by modulating pseudopod behaviour. I will describe evidence from different sources, including: (1) the pathways that regulate SCAR/WAVE, the principal regulator of pseudopod actin, and myosin II, which provides contractile force; (2) quantitative analyses of real cells chemotaxing under different conditions; (3) computation modelling of cell migration and chemotaxis using a conceptually simple, pseudopod-centred algorithm and its predictions for real cell migration. Hope to see you there! Best wishes, Robert ---------------------------------------------------------------- Dr. Robert Endres Reader in Systems Biology Imperial College London Tel: +44 (0)20 7594 9537 r.endres@imperial.ac.uk Personal: http://www.imperial.ac.uk/people/r.endres Group: http://www3.imperial.ac.uk/biologicalphysics