FYI: Date: 29/01/2020 at 1pm Location: SAF G34
From: Endres, Robert G
Sent: 27 January 2020 22:29
To: LCN Administrator <lcn-administrator@imperial.ac.uk>; Williamson, Andrew <andrew.williamson@imperial.ac.uk>; Bruckbauer, Andreas <a.bruckbauer@imperial.ac.uk>
Cc: French, Paul (PHOT) M W <paul.french@imperial.ac.uk>; Aofolaju, Kemi <a.aofolaju@imperial.ac.uk>
Subject: Wednesday 29/01/2020 - joint PoL and DoLS seminar by Prof. Holger Kress - SAF G34 at 1pm
Hi all,
this is a joint Physics-of-Life network and DoLS seminar. Holger Kress will discuss using holographic optical tweezers
to feed multiple particles to cells to study cellular uptake (phagocytosis) and intracellular transport via motor proteins.
Might be of interest to the physics, bioengineering, imaging, and nanotechnology students and researchers. Can you
send out via your mailing lists please?
Best,
Robert
----------------------------------------------------------------
Professor Robert Endres
Biological Physics Group
Imperial College London
Tel: +44 (0)20 7594 9537
r.endres@imperial.ac.uk
http://www.imperial.ac.uk/people/r.endres
From: Nurboja, Sandrine A C <s.nurboja@imperial.ac.uk>
Sent: Thursday, January 16, 2020 9:58 AM
To: DoLS Staff and PGR Students <ls_all_dl@imperial.ac.uk>; CMBI DL <cmbidl@imperial.ac.uk>; Life Sciences - Biochemistry - UG3 <bs-bioch-ug3-dl@imperial.ac.uk>;
Life Sciences - Biochemistry - UG2 <bs-bioch-ug2-dl@imperial.ac.uk>; Life Sciences - Biochemistry - UG3 <bs-bioch-ug3-dl@imperial.ac.uk>; Life Sciences
- Biology - UG1 <bioug1dl@imperial.ac.uk>; Life Sciences - Biology - UG2 <bioug2dl@imperial.ac.uk>; Life Sciences - Biology - UG3 <bioug3dl@imperial.ac.uk>
Subject: 29/01/2020 - LIFE SCIENCES DEPARTMENTAL SEMINAR SAF G34
Dear All,
See below details of the next Life Sciences Departmental Seminar :
Date:
29/01/2020 at 1pm
Location: SAF G34
Speaker:
Holger Kress
Biological Physics Group
University of Bayreuth
Title:
“Physical determinants of the cellular uptake and intracellular
transport during phagocytosis”
Abstract:
Phagocytosis is an essential part of the human immune system and an evolutionary highly conserved fundamental cellular process. A large number of
molecules that are involved in phagocytosis are known already. However, a quantitative physical understanding of this intrinsically mechanical process is still lacking. Therefore, we investigate physical determinants of the phagocytic uptake and transport.
We examine the cellular resolution limit for particle uptake by using holographic optical tweezers in combination with correlative light and electron microscopy to measure the ability of cells to discriminate between two spatially separated objects. These
studies provide for example insights into the spreading of cell signaling during particle uptake. In addition, we investigate the influence of basic spatial factors for the transport of intracellular organelles and we show that not all phagosomes are transported
directly from the cell periphery to the perinuclear region, but that they exhibit more complex transport characteristics, which depend strongly on the size of the phagosomes. This transport behavior might be the foundation for a size-dependent cellular sorting
mechanism for organelles. To gain insights into the underlying causes for this process, we quantify how the intracellular transport forces scale with the organelle size by using magnetic tweezers. These measurements provide cues for the numbers of participating
motors and their potential cooperative behavior during the transport of different-sized organelles. In summary, we expect our results to pave the way for a deeper quantitative understanding of the cellular uptake and intracellular transport during phagocytosis
and thus enable the development of new and more comprehensive models for this important cellular process.
Host: Robert Endres
If you would like to meet with the speaker, please contact Robert
r.endres@imperial.ac.uk
who will arrange a schedule.
All welcome.
Many thanks
Sandrine
Sandrine Nurboja
Departmental and Projects Administrator
Life Sciences Department
Imperial College
502 Sir Alexander Fleming Building
London SW7 2AZ
Tel 020 7594 5393