This is my pleasure to
announce the next LIVIm Club, which will take place on Monday
20th May at the London Research Institute
- Dr Tim Witney (Comprehensive Cancer Imaging Centre &
MRC-CSC Molecular Therapy group - Imperial College London)
Please note that registration
is FREE but REQUIRED if you have not registered previously
(see poster)
LIVIm
Monday May 20th
Venue: Room 37A&B, London Research Institute, Cancer
Research UK, 44
Lincoln’s Inn Fields – WC2A 3LY London
17.00 – 17.50 Professor Kurt Anderson, Beatson Institute and
University of Glasgow
Quantitative in vivo imaging of disease and response to
therapy
• FRAP and FLIM-FRET can be used to assess molecular dynamics
at the cellular and subcellular
level in vivo.
• Mutant p53 mobilises eCadherin in the PKC model of
pancreatic cancer, which is reversed
by dasatinib treatment.
• FLIM analysis of a Src FRET reporter reveals spatial &
temporal dynamics and antimetastic
drug treatment in different regions of sub cut tumours and
with respect to local
vasculature
18.00 – 18.30 Dr Tim Witney, Comprehensive Cancer Imaging
Centre & MRC-CSC Molecular Therapy
group (Aboagye Lab)
Non-invasive imaging of tumour glycogen storage by 18F-NFTG
positron emission tomography
• Tumours accumulate glycogen at levels far higher than normal
tissues
• 18F-NFTG annotates glycogen storage in cancer cells /
tumours in vivo
• Imaging de novo glycogenesis can inform Rab25 oncogene
status, which is of prognostic
significance in tumours
• Glycogen status, measured by 18F-NFTG PET, is a marker of
tumour proliferative state
Drinks and munchies are provided after the talks to follow the
conversations in an informal atmosphere
Registration to LIVIm is FREE but REQUIRED
People registered for previous meetings do not have to
register again
For registration, please email your details and affiliation to
LIVIm@cancer.org.uk
If you have not registered in advance you will be refused
entry