Please see this interesting PostDoc opportunity with Patrick Chinnery (Cambridge Mitochondrial Biology Unit/Clinical Neuroscience) and Nick Jones (Imperial Maths): A. ------------------------------------ PDRA in Microscopy of Mitochondrial Copy-Number https://www.imperial.ac.uk/jobs/description/NAT00744/research-associate-micr... Closing date 14 September 2020 Applications are invited for a 2-year PostDoc joint between the labs of Patrick Chinnery (Cambridge Mitochondrial Biology Unit/Clinical Neuroscience) and Nick Jones (Imperial Maths) using microscopy to study the control of mitochondrial genome copy-number. Cells control the copy-number of their mitochondrial DNA (mtDNA) yet the process of this control has been poorly characterised. Through a combination of microscopy, image analysis and some flow-cytometry the appointee will attempt to understand and perturb this system. Beyond being of fundamental relevance to our biological understanding; the character of control of mtDNA defines the rate and manner in which mutant mtDNA expands through cellular populations. The expansion of mutant mtDNA is implicated in ageing: thus the project seeks to identify some of the basic mechanisms of ageing. The project is a close collaboration between two groups that both have a track record of working at the interface between experiment and theory and aligns with another PDRA and 2 PhDs joint between our groups. Candidates might have backgrounds in quantitative biology/microscopy or experimental biological physics/biophysics. The core skills will be single-cell microscopy with some image analysis. The appointee will join the Centre for the Mathematics of Precision Healthcare, the Cambridge Mitochondrial Biology unit and a new subgrouping in Imperial Mathematics on Single Cell theory and data. We welcome candidates from all backgrounds and value a supportive environment prioritising purposeful happiness. We anticipate an ~October 2020 start. Relevant links: https://www.imperial.ac.uk/jobs/description/NAT00498/research-associate http://systems-signals.blogspot.com/ https://www.imperial.ac.uk/people/nick.jones/ http://www.mrc-mbu.cam.ac.uk/people/patrick-chinnery http://www.imperial.ac.uk/mathematics-precision-healthcare/ -- Department of Mathematics - Imperial College London