The drug Viagra is typically of the "Internet age", with prescriptions for the pill being taken on-line (http://thepillbox.com/buyviagra.htm, 10 pills - $105.09 ) and much other information such as side effects etc being so documented. Being unable to find any structural information, I created http://www.ch.ic.ac.uk/motm/viagra.html Of some minor interest is that two of the CAS hits on this system appear to show the wrong tautomer. Anyone found an exemplary page on the role of nitric oxide in the metabolic sequence? Finally, I might note with interest an anecdote by a 2nd year student here. Part of their degree consists of a "chemical IT" course, in which they are trained to use a variety of chemical information tools, and then demonstrate their skills by creating a project. Quite a few students mount the project on their personal web site provided by ISPs. This student came to tell me that in about 4-6 weeks on-line, their particular project had notched up about 4000 hits (they had inserted a counter), and he was now being sent emails from what appeared quite senior researchers asking about details. It certainly seemed quite a motivator for him! I wonder how many laboratory notebook writeups have had a similar impact! Dr Henry Rzepa, Dept. Chemistry, Imperial College, LONDON SW7 2AY; mailto:rzepa@ic.ac.uk; Tel (44) 171 594 5774; Fax: (44) 171 594 5804. URL: http://www.ch.ic.ac.uk/rzepa/ chemweb: A list for Chemical Applications of the Internet. To post to list: mailto:chemweb@ic.ac.uk Archived as: http://www.lists.ic.ac.uk/hypermail/chemweb/ To (un)subscribe, mailto:majordomo@ic.ac.uk the following message; (un)subscribe chemweb List coordinator, Henry Rzepa (mailto:rzepa@ic.ac.uk)
May I comment on the CAS name of Viagra - more properly known by its generic name Sildenafil. All structures in CAS which are tautomers are named by the tautomer which gives the preferred name irrespective of the more probable tautomer (see Index Guide Appendix IV para 122). Hence a hydrogen at N-4 of the heterobicyclic ring system is preferred to one at N-6. At the British Pharmacopoeia Commission we named it: 5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1,6-dihydro-1-methyl- 3-propylpyrazolo[4,3-d]pyrimidin-7-one which is I think the most likely tautomer. Gerry Moss _________________________________________________________________________ Dr GP Moss Telephone: +44 171 775 3262 Department of Chemistry Queen Mary & Westfield College Facsimile: +44 181 981 8745 Mile End Road London E1 4NS, United Kingdom E-mail: g.p.moss@qmw.ac.uk World Wide Web server: http://www.chem.qmw.ac.uk/ IUPAC chemical nomenclature data base: http://www.chem.qmw.ac.uk/iupac/ IUBMB biochemical nomenclature data base: http://www.chem.qmw.ac.uk/iubmb/ chemweb: A list for Chemical Applications of the Internet. To post to list: mailto:chemweb@ic.ac.uk Archived as: http://www.lists.ic.ac.uk/hypermail/chemweb/ To (un)subscribe, mailto:majordomo@ic.ac.uk the following message; (un)subscribe chemweb List coordinator, Henry Rzepa (mailto:rzepa@ic.ac.uk)
participants (2)
- 
                
                G.P.Moss
- 
                
                Rzepa, Henry