Johnny Gasteiger has asked me to post this message. Abstracts should be submitted through OASYS well before November 23. Wendy Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com Symposium on de novo design and synthetic accessibility at the ACS Meeting in Atlanta, GA, USA on March 26-30, 2006 Several inroads have been made to the design of novel molecules as potential leads for new drugs. These methods may be either based on a knowledge of the 3D structure of the target protein and its binding pocket or may rest on an analysis of a series of ligands of the protein. The molecules thus designed have quite different complexity and thus an estimate on how easy - or difficult - their synthesis might be is of paramount importance for the medicinal chemist. The symposium intends to show the present state of affairs both in the de novo design of lead structures and in methods for estimating the synthetic accessibility of organic structures. If you are interested in presenting a contribution to this symposium please contact Johnny Gasteiger Computer-Chemie-Centrum University Erlangen-Nuremberg Naegelsbachstr. 25 91052 Erlangen Germany Gasteiger@chemie.uni-erlangen.de