The editors of the Journal of Chemical Information & Modeling and the authors of the manuscript, Llinàs, A.; Glen, R.; Goodman, J., Solubility Challenge: Can You Predict Solubilities of Thirty-Two Molecules Using a Database of One Hundred Reliable Measurements?, J. Chem. Inf. Modeling, ASAP Release Date: July 15, 2008. have arranged a Solubility Prediction Challenge. The goal of this Challenge is not to identify a winning group, but rather to advance our general understanding of how to better perform solubility estimations. Because of your work in the area of physical property and ADME calculations and predictions, we would like to encourage you to consider being a participant in this Solubility Prediction Challenge. All predictions are due 8 weeks from the release date, July 15, 2008, of the manuscript as part of the JCIM ASAP and the initial posting of the Challenge announcement on the JCIM homepage; that is, no later than Friday, September, 19, 2008. Participants are to provide a five letter contestant code name which will be used in reporting the results of the Challenge. No actual names of the participants will be published with the results of the Challenge. Additional details and rules of the Challenge are given in the Challenge announcement on the JCIM homepage beginning July 15, 2008. Sincerely, The JCIM Editors Journal of Chemical Information and Modeling Professor William L. Jorgensen, Editor in Chief Yale University Department of Chemistry P. O. Box 208107 New Haven, CT 06520-8107 Phone: 203-432-4118 Fax: 202-513-8628 E-mail: eic@jcim.acs.org Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./fax +44 (0)1477 533837 wendy@warr.com http://www.warr.com