Chemical Information and Computation 2015, Number One; 249th ACS National Meeting and Exposition; Denver, CO, March 22-26, 2015 We are pleased to announce the publication of our 45th report in this series. It covers a selection of 28 papers, in detail, from the following technical symposia: * Ligand-based Drug Discovery * Molecular and Structural 2D and 3D Chemical Fingerprinting: Computational Storing, Searching and Comparing Molecular and Chemical Structures * Getting to the Best Reaction: Tools for Finding a Needle in a Haystack * Research Results: Reproducibility, Reporting, Sharing and Plagiarism * Development and Use of Data Format Standards for Computational Chemistry * Defining "Value" in Scholarly Communications: Evolving Ways of Evaluating Impact on Science (one paper on the impact of crystal structures) There is also the usual news section covering people, awards, and 65 organizations. The report is over 220 pages long, in full color. Full contents list and order forms at http://www.warr.com. Wendy Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./Fax +44 (0)1477 533837 wendy@warr.com<mailto:wendy@warr.com> http://orcid.org/0000-0002-7064-4739 http://www.warr.com<http://www.warr.com/> Skype: wendyannewarr Twitter: @WendyAnneWarr