Chemical Information and Computation 2015, Number Two. 250th ACS National Meeting and Exposition; Boston, MA, August 16-20, 2015 Now available, our 46th report in this series has transcripts of technical presentations on visualizing chemistry data to guide lead optimization; and retrosynthesis, synthesis planning, and reaction prediction; with over 200 literature references. A lengthy summary of the Herman Skolnik Award symposium (already available on open access at http://bulletin.acscinf.org/node/814) is added for completeness. There is also the usual news section covering people, awards, and industry news, and recent developments at nearly 70 organizations in the computational chemistry, cheminformatics, chemical information, and publishing markets. The report is over 220 pages long, in full color. Order forms at http://www.warr.com<http://www.warr.com/>. Contents list at http://www.warr.com/morepubs.html. Wendy Dr. Wendy A. Warr Wendy Warr & Associates 6 Berwick Court, Holmes Chapel Cheshire, CW4 7HZ, England Tel./Fax +44 (0)1477 533837 wendy@warr.com<mailto:wendy@warr.com> http://orcid.org/0000-0002-7064-4739 http://www.warr.com<http://www.warr.com/> Skype: wendyannewarr Twitter: @WendyAnneWarr