I would like to update people on our (Tripos') progress in the area of web chemistry and let you know about a new pharmacophore detection tool using web technology called GASP. GASP is based on work in the Willett laboratory at Sheffield University (Jones, Willett & Glen, J. Comp.-Aided Mol. Design (1995) 9:532-549. The interface includes an updated visualization Java applet and deals with issues surrounding job control via the web. As many of you have seen, we previously implemented a prototype web application called "Fetch and Sketch" which can be accessed at www.tripos.com. The response to the prototype has been overwhelmingly positive. In fact, the WebSketch applet was voted one of the best Java applets of the year by Gamelan. My thanks to everyone who visited the site. The comments were extremely helpful. GASP is now installed on www.tripos.com - this is a complete installation of the program, not a mock-up, except that launching jobs has been disabled. Please check it out and sent us your comments. All feedback is welcome. ------------------------------------------------------------------------------ Dean Goddette, Ph.D. Senior Product Manager TRIPOS, Inc., 1699 S. Hanley Road, St. Louis, MO 63144 ph. (314) 647-1099 X3386 fax: (314) 647-9241 Tripos Announces Release of New Web-based Pharmacophore Detection Program Tripos is pleased to announce the release of GASP v1.0, a program for molecular alignment and pharmacophore detection. GASP produces better alignments than other programs because of its unique fitness function coupled with a genetic algorithm that drives the conformational search. No precalculation of conformations is needed! GASP has been implemented for use on internal company networks for sharing information with other scientists. Using tools developed for the Internet, GASP results can be viewed by scientists anywhere in the company on any platform. The only requirements are that the chemist be connected to the company network and have a "browser". GASP handles the rest. GASP can be previewed by visiting www.tripos.com. This is a complete installation of GASP, not a mock-up! Launching of jobs has been disabled but visitors can get a feel for the program directly. Tripos strongly recommends the use of Netscape Navigator 2 with GASP. GASP uses Java for some of the interactive visualization tools. Other browsers can be used but only static images will be displayed. GASP is based on work in the Willett laboratory at Sheffield University (Jones, Willett & Glen, J. Comp.-Aided Mol. Design (1995) 9:532-549. ------------------------------------------------------------------------------ Dean Goddette, Ph.D. Senior Product Manager TRIPOS, Inc., 1699 S. Hanley Road, St. Louis, MO 63144 ph. (314) 647-1099 X3386 fax: (314) 647-9241 to:chemweb@ic.ac.uk ----- chemweb: A list for Chemical Applications of the Internet. Archived as: http://www.ch.ic.ac.uk/hypermail/chemweb/ To unsubscribe, send to listserver@ic.ac.uk the following message; unsubscribe chemweb List coordinator, Henry Rzepa (rzepa@ic.ac.uk)