Bob Clark has asked me to draw your attention to this upcoming
symposium:
A symposium is being organized for this fall's ACS meeting in Washington
DC (Aug 28-Sep 1, 2005) entitled:
(Q)SAR in Today's Agrochemistry
The discovery and development of any biologically active small molecule
necessarily entails biological or biochemical testing of candidate
compounds and relating the results obtained from such testing back to
chemical structure, i.e., establishing structure activity relationships
(SARs). This symposium will embrace application of qualitative as well
as quantitative analytical methods to agrochemical problems in
particular and to in vivo (or ex vivo) assays in general, as well as
lead identification (triage) techniques. Talks related to the design of
primary and secondary screens will also be appropriate, particularly as
they relate to the ability to subsequently carry out meaningful SAR
analysis.
Many of the difficulties encountered in constructing structure-activity
relationships using agrochemical data are also encountered by those in
pharmaceutical discovery and development who work, as is more and more
common, with whole cell assays. This includes many of the
environmental, toxicological and ADME screens now in use in both
industries. The symposium is being organized to provide a forum for
those with experience in this general realm to share what they have
learned with those coming from a more enzyme-based SAR background.
Papers involving agrochemical applications are especially encouraged,
but any discussion of the challenges that arise in similar applications
- e.g., whole cell and intact animal assay systems - are invited as
well. Please submit abstracts directly to the OASYS system:
http://oasys.acs.org/acs/230nm/agro/papers/index.cgi
The deadline for abstract submission is April 26, 2005.
Bob Clark
Tripos, Inc.
1699 S. Hanley Rd.
St. Louis MO 63144
bclark(a)tripos.com
Wendy
Dr. Wendy A. Warr
Wendy Warr & Associates
6 Berwick Court, Holmes Chapel
Cheshire, CW4 7HZ, England
Tel./fax +44 (0)1477 533837
wendy(a)warr.com http://www.warr.com
This was in the Managing Information newsletter:
"Elsevier has revealed a new open source cross-referencing tool for
XQuery applications, called xqDoc, developed by Darin McBeath, an
Elsevier employee in the company's Advanced Technology Group. The tool
is now freely available to the open source community.
XQuery is a new query/programming language based on XML and used in
conjunction with XML databases such as MarkLogic, a commercial database,
and eXist, on the open source side.
The goal of xqDoc is to provide a vendor neutral solution for
documenting XQuery applications, as well as tools to generate a
user-friendly representation of this documentation and cross-referencing
information (e.g., how different functions are used by each other).
This is accomplished through several components, including a new
commenting convention that extends the currently defined XQuery comment
style.
This convention is modeled after Java's Javadoc commenting style, and
provides a simple, uniform way to document XQuery source code. Javadoc
is a widely used tool for providing the same sort of information for
Java programs that xqDoc provides for XQuery programs. It is hoped that
xqDoc achieves the same level of adoption and success for XQuery that
Javadoc has for Java.
For further information on xqDoc, visit www.xqdoc.org
<http://www.xqdoc.org/> "
Wendy
Dr. Wendy A. Warr
Wendy Warr & Associates
6 Berwick Court, Holmes Chapel
Cheshire, CW4 7HZ, England
Tel./fax +44 (0)1477 533837
wendy(a)warr.com http://www.warr.com
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Hi,
March's MOTM is hexenal, the smell of newly mown grass. It has been
written by Simon Cotton from Uppingham School,
Rutland, UK, and various enhanced versions of the page are available.
http://www.chm.bris.ac.uk/motm/motm.htm#mar2005
regards,
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Dr Paul May, School of Chemistry, University of Bristol, BRISTOL BS8 1TS, UK
tel: +44 (0)117 9289927 fax: +44 (0)117 9251295 mobile: +44(0)7811371539
Email: Paul.May(a)bristol.ac.uk
Web: http://www.chm.bris.ac.uk/staff/pwm.htm
MOTM: http://www.chm.bris.ac.uk/motm/motm.htm
"Dopeler effect: The tendency of stupid ideas to seem smarter when they
come at you rapidly"
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